Fish Oil Doesn't Cut Diabetes Patients’ Heart Risk
If you have diabetes or prediabetes, fish oil supplements
might not be so helpful after all in cutting heart disease risk.
That's the conclusion of a large study published in The
New England Journal of Medicine.
Fish oil supplements contain omega-3 fatty acids. The
American Heart Association says omega-3s have been shown to benefit the hearts
of people at high risk for heart disease.
But in the new study, people with type 2 diabetes or
prediabetes who took omega-3 fatty acid supplements were no less likely to die
or suffer a heart attack or stroke than patients who did not take the
supplements.
Last April, a review of studies involving more than
20,000 patients with heart disease found the same thing.
People in the latest study who took a fish oil capsule
every day containing about 1 gram of omega-3 fatty acids had the same risk of
heart attack, stroke, and death as people who did not over six years of
follow-up.
Study researcher Hertzel Gerstein, MD, of McMaster
University in Ontario, Canada, says the research as a whole offers no evidence
to support the use of omega-3 supplements by people with diabetes or
prediabetes to lower heart risk.
"We found no effect, either positive or
negative," he tells WebMD. "One capsule of omega-3 fatty acid daily
did not have any effect on future heart outcomes."
The study included about 12,500 patients with diabetes or
prediabetes who had established heart disease or were at high risk for having a
heart attack or stroke. The participants took either a 1-gram fish oil capsule
a day or a placebo capsule that contained no omega-3.
The patients who took omega-3s had a reduction in
triglyceride levels over six years of follow-up. Triglycerides are a type of
fat found in blood. High triglycerides are linked to heart disease.
But the death rate from heart attacks and strokes was the
same for patients who took omega-3s and patients who had the placebo. Also,
both groups had the same rate of heart attacks, strokes, and deaths from
arrhythmias and other heart-related causes.
More than half (60%) of the study participants had
already experienced a heart attack or stroke when they entered the study. Most
of these patients were taking drugs such as statins, ACE inhibitors, and
aspirin to lower their risk for a second heart attack or stroke.
American Heart Association president Donna K. Arnett,
PhD, says it remains to be seen if people who aren't on optimal prevention
treatments benefit from taking fish oil.
It is also not clear if people with a lower risk for
heart attack and stroke benefit, she says.
At least three studies in low-risk people are under way.
Results from the first of these studies should be published within the next few
months.
"Until the results from these trials are known, we
can't really say if omega-3 supplementation is beneficial for people at lower
risk," Arnett tells WebMD.
Gerstein says the latest findings do not contradict studies
showing that eating more fatty fish and other omega-3-rich foods is good for
the heart.
"People who eat a diet rich in omega-3 fatty acids
eat fewer foods that may be harmful, such as red meat," he says.
"Eating more fish and less red meat may be better for health, but it may
not be the omega-3."
The study was funded by the drug maker Sanofi.
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